Restylane is an injectable dermal filler that was approved by the FDA (Food and Drug Administration) in 2003. Restylane is produced by fermentation in bacterial cultures of equine streptococci. The main component is hyaluronic acid which binds to water and volumises, softens, and hydrates skin. It can, therefore reduce the contours of wrinkles and lines or enhance areas such as the lips or cheeks. In addition to these benefits, it plays a role in cell growth, membrane receptor function, and adhesion. The hyaluronic acid in Restylane is highly cross-linked, making these fillers one of the stiffest hyaluronic acid fillers. This dermal filler has been used for correction of the nasolabial folds, marionette lines, tear troughs, and glabellar frown lines in addition to lip enhancement and cheek augmentation. Other clinical uses include correction of the jowl and nasal deformities. In general, most patients can expect 6 months of correction, if not longer. The procedure only takes a matter of minutes. A thin needle is used to inject small volumes of the filler into the specific area being treated. There is minimal bleeding, and mild discomfort during the procedure. Afterwards there may be some very mild bruising, but almost all normal activities may be immediately resumed, so there is virtually no down time.

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